The FDA approved a new weight loss drug combination - Phentermine and Topirmate in July, 2012 for people who are obese or those that are overweight with obesity related medical conditions. Let us look at the evidence, indications, side effects, cost, and how to find a physician that prescribe these medications for you. What is Phentermine ? Phentermine is one of the oldest weight loss medications and is an appetite suppressant to help reduce weight in obese patients when used short-term and combined with exercise, diet, and behavioral modification. It is typically prescribed for individuals who are at increased medical risk due to their weight. What is Topiramate ? Topiramate (brand name Topamax ) is an anticonvulsant (antiepilepsy) drug. It was most recently approved for weight loss by the FDA in combination with phentermine called Qsymia ® . Why combination medications are used for weight loss? The appetite and satiety centers in the brain are influenced by a o