W8MD physician-supervised care Nonsurgical Medical Weight-Loss Options A current guide to nutrition, low-calorie and VLCD programs, traditional weight-loss pills, GLP-1 injections, oral incretin medicines, sleep care and maintenance. NYC: 718-946-5500 Philadelphia: 215-676-2334 Quick answer: Nonsurgical weight management can include an individualized reduced-calorie eating plan, physical activity, behavioral treatment, meal replacements, prescription pills, GLP-1 or GIP/GLP-1 medicines, oral incretin treatment, sleep-apnea care and long-term maintenance. The safest combination depends on medical history, BMI, weight-related conditions, preferences, previous response, insurance and budget. More than seven in ten U.S. adults have overweight or obesity, and recent national data estimate that about 40% of adults have obesity. These figures matter because excess weight can increase the likelihood of type 2 diabetes, cardiova...